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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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407950
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Overview

Key Spec Table

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

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407950-10MG
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      407950-1MG
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          407950-5MG
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              Description
              OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
              Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
              Catalogue Number407950
              Brand Family Calbiochem®
              References
              ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
              Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
              Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
              Lee, H.C. 1993. J. Biol. Chem. 268, 293.
              Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
              Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
              Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
              Product Information
              CAS number56092-81-0
              ATP CompetitiveN
              FormWaxy solid
              Hill FormulaC₄₁H₇₂O₉
              Chemical formulaC₄₁H₇₂O₉
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
              Biological Information
              Primary TargetMobile ion carrier for Ca2+
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableN
              Safety Information according to GHS
              RTECSNO0600000
              Safety Information
              R PhraseR: 22

              Harmful if swallowed.
              S PhraseS: 36

              Wear suitable protective clothing.
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Global Trade Item Number
              Catalogue Number GTIN
              407950-10MG 04055977211566
              407950-1MG 04055977211559
              407950-5MG 04055977211573