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579053 InSolution™ TAPI-1 - Calbiochem

InSolution™ TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.

InSolution™ TAPI-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MMPs and TACE
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579053
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₃₇N₅O₅

Pricing & Availability

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579053-500UG
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      Description
      Catalogue Number579053
      Brand Family Calbiochem®
      References
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
      Hill FormulaC₂₆H₃₇N₅O₅
      Chemical formulaC₂₆H₃₇N₅O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.
      Biological Information
      Primary TargetMMPs and TACE
      Primary Target IC<sub>50</sub>8.09 µM, 3.61 µM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      579053-500UG 04055977265385

      Documentation

      InSolution™ TAPI-1 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ TAPI-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      579053
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      DescriptionA structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).
      FormLiquid
      FormulationA 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₃₇N₅O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant