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527451 InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem

The InSolution™ PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I

Primary Target: PKR
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527451
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
608512-97-6C₁₃H₈N₄OS

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      Description
      OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.
      Catalogue Number527451
      Brand Family Calbiochem®
      SynonymsC16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
      References
      ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Product Information
      CAS number608512-97-6
      FormLiquid
      FormulationA 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.
      Hill FormulaC₁₃H₈N₄OS
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKR
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      527451-5MG 04055977270372

      Documentation

      InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      527451

      References

      Reference overview
      Zhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-September-2012 JSW
      SynonymsC16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
      DescriptionAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.
      FormLiquid
      FormulationA 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number608512-97-6
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.