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504776 InSolution™ Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

InSolution™ Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Lygosporin A, Zygosporin A, NSC 209835

Primary Target: microfilaments
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504776
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
22144-77-0C₃₀H₃₇NO₆

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      Description
      Catalogue Number504776
      Brand Family Calbiochem®
      SynonymsLygosporin A, Zygosporin A, NSC 209835
      References
      ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
      Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
      Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
      Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
      Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
      Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
      Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
      Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
      Product Information
      CAS number22144-77-0
      FormLiquid
      FormulationA 10 mM (1 mg/197 µL) sterile-filtered solution of Cytochalasin D, Zygosporium mansonii (Cat. No. 250255) in DMSO.
      Hill FormulaC₃₀H₃₇NO₆
      Chemical formulaC₃₀H₃₇NO₆
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetmicrofilaments
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 24/25

      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.04776.0001 04055977244120

      Documentation

      InSolution™ Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
      Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
      Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
      Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
      Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
      Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
      Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
      Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-June-2013 JSW
      SynonymsLygosporin A, Zygosporin A, NSC 209835
      DescriptionA cell-permeable fungal toxin that is approximately 10 times more potent than cytochalasin B (Cat. No. 250233) in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments at 10 µM. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Cytochalasin D also exhibits antibiotic and anti-tumor properties.
      FormLiquid
      FormulationA 10 mM (1 mg/197 µL) sterile-filtered solution of Cytochalasin D, Zygosporium mansonii (Cat. No. 250255) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number22144-77-0
      Chemical formulaC₃₀H₃₇NO₆
      Structure formulaStructure formula
      Purity≥98% by TLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Irritant
      ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
      Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
      Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
      Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
      Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
      Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
      Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
      Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.