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171264 InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem

The InSolution™ AMPK Inhibitor, Compound C•2HCl, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O

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171264
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
866405-64-3C₂₄H₂₅N₅O

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      Description
      OverviewA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
      Catalogue Number171264
      Brand Family Calbiochem®
      SynonymsAMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O
      References
      ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Product Information
      CAS number866405-64-3
      FormLiquid
      FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
      Hill FormulaC₂₄H₂₅N₅O
      Chemical formulaC₂₄H₂₅N₅O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      171264-2MG 04055977207200

      Documentation

      InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      171264

      References

      Reference overview
      Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2012 JSW
      SynonymsAMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O
      DescriptionA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice.
      FormLiquid
      FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number866405-64-3
      Chemical formulaC₂₄H₂₅N₅O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
      ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.