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401002 Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem

Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rlbTx, Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ

Primary Target: High conductance Ca2+-activated K+ channels
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401002
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Overview

Replacement Information

Key Spec Table

CAS #
129203-60-7

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      Description
      OverviewRecombinant Buthus tamulus iberiotoxin expressed in E. coli. Acts as a selective, reversible blocker of high conductance Ca2+-activated K+ channels (IC50 = 250 pM).
      Catalogue Number401002
      Brand Family Calbiochem®
      SynonymsrlbTx, Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
      References
      ReferencesVanelli, G., et al. 1994. J. Appl. Physiol. 76, 1098.
      Garcia, M.L., et al. 1991. J. Bioeng. Biomembr. 23, 615.
      Galvez, A., et al. 1990. J. Biol. Chem. 265, 11083.
      Product Information
      CAS number129203-60-7
      ATP CompetitiveN
      FormSalt-free lyophilized solid
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activitypotently inhibits Ca2+-activated K+ channels expressed in Xenopus oocytes
      Primary TargetHigh conductance Ca2+-activated K+ channels
      Primary Target IC<sub>50</sub>250 pM against high conductance Ca2+-activated K+ channels
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequencePyr-Phe-Thr-Asp-Val-Asp-Cys⁷-Ser-Val-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys²⁸-Met-Gly-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Gln-OH (disulfide bonds: 7 →28; 13 → 35; 17 → 33)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 3 months at -20°C or up to 2 weeks at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      401002-10UG 04055977189360

      Documentation

      Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      401002

      References

      Reference overview
      Vanelli, G., et al. 1994. J. Appl. Physiol. 76, 1098.
      Garcia, M.L., et al. 1991. J. Bioeng. Biomembr. 23, 615.
      Galvez, A., et al. 1990. J. Biol. Chem. 265, 11083.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsrlbTx, Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
      DescriptionRecombinant Buthus tamulus iberiotoxin expressed in E. coli. A single polypeptide chain of 37 amino acids that displays about 68% sequence homology with charybdotoxin (ChTx). Acts as a selective, reversible blocker of high conductance, Ca2+-activated K+ channels (PK,Ca). rIbTx does not block other types of voltage-dependent ion channels, especially other types of K+ channels that are sensitive to inhibition by ChTx. Shown to block PK,Ca in excised membrane patches from bovine aortic smooth muscle, acting exclusively at the outer face of the channel (IC50 = 250 pM). Causes a decrease in probability of channel opening and the channel open mean time. rIbTx appears to modulate ChTx binding by an allosteric mechanism.
      FormSalt-free lyophilized solid
      CAS number129203-60-7
      Peptide SequencePyr-Phe-Thr-Asp-Val-Asp-Cys⁷-Ser-Val-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys²⁸-Met-Gly-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Gln-OH (disulfide bonds: 7 →28; 13 → 35; 17 → 33)
      Purity≥98% by HPLC
      Biological activitypotently inhibits Ca2+-activated K+ channels expressed in Xenopus oocytes
      SolubilityReconstitute in Tris-buffered saline (100 mM NaCl, 10 mM Tris-HCl, pH 7.5) containing 0.1% BSA.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 3 months at -20°C or up to 2 weeks at 4°C.
      Toxicity Harmful
      ReferencesVanelli, G., et al. 1994. J. Appl. Physiol. 76, 1098.
      Garcia, M.L., et al. 1991. J. Bioeng. Biomembr. 23, 615.
      Galvez, A., et al. 1990. J. Biol. Chem. 265, 11083.