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509225 IFN-α Receptor 2 Agonist, RO8191 - Calbiochem

IFN-α Receptor 2 Agonist, RO8191 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2,4-bis(Trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl)-1,3,4-oxadiazole, 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1, 2-a][1, 8]naphthyridine, IFN-α Receptor 2 Agonist, RO4948191, IFN-α R2 Agonist, Interferon-α Receptor 2 Agonist

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      Overview

      Key Spec Table

      Empirical Formula
      C₁₄H₅F₆N₅O
      Description
      Overview

      This product has been discontinued.



      A non-cytotoxic imidazonaphthyridine compound that directly binds interferon-α receptor 2 (IFNAR2) extracelluar domain in a 1:1 ratio and activates cellular signaling via IFNAR2 homodimerization in an IFNAR1-independent manner, eliciting similar, but not identical, signaling events as those seen with IFN--α, IFN--β, or IFN--γ stimulation. While being a much stronger stimulant of STAT3 Y705/S727 & JAK1 Y1022/1023 phosphorylations, RO8191 is ineffective in inducing IFNAR1-dependent Tyk2 Y1054/1055 phosphorylations (10 µM for 15 min; in Huh-7 cultures). Effectively boosts host anti-HCV (EC50 = 200 nM in Huh-7-derived HCV replicon cell line) and anti-EMCV (90% viability with 1.23 µM RO8191 in EMCV-infected A549 cultures) by inducing ISG/IFN-stimulated genes expression both in cultures in vitro and in mice (30 mg/kg p.o.) in vivo
      Catalogue Number509225
      Brand Family Calbiochem®
      Synonyms2-(2,4-bis(Trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl)-1,3,4-oxadiazole, 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1, 2-a][1, 8]naphthyridine, IFN-α Receptor 2 Agonist, RO4948191, IFN-α R2 Agonist, Interferon-α Receptor 2 Agonist
      References
      ReferencesKonishi, H., et al. 2012. Sci. Rep. 2, 259.
      Product Information
      FormPale yellow powder
      Hill FormulaC₁₄H₅F₆N₅O
      Chemical formulaC₁₄H₅F₆N₅O
      ReversibleY
      Quality LevelMQ200
      Biological Information
      Primary Targetinterferon-α receptor 2 (IFNAR2)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      509225 0