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373501 Herg Activator, NS1643 - CAS 448895-37-2 - Calbiochem

373501
  
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      448895-37-2C₁₅H₁₀F₆N₂O₃
      Description
      Overview

      This product has been discontinued.



      A diphenolurea compound that selectively activates human ether-a-go-go-related gene (hERG) K+-channel (EC50 = 10.5 µM). Shown to significantly increase both steady-state and peak tail currents of hERG channels, but exhibits only a trivial effect on Kv4.3 and Kv1.5 channels. Causes a significant reduction in action potential duration (APD90 ) in patch clamp assays in Xenopus oocytes, HEK293 cells, and guinea pig cardiamyocyes that can be reversed by the addition of E-4031 (Cat. No. 324470), a specific blocker of hERG channels. Also shown to activate IKr channel in cardiomyocytes and increase post-repolarization refractory time thereby alleviating hyper-excitability and producing antiarrhythmic effects. It can also restore IKr reduced by down-regulation of IKr expression.

      Catalogue Number373501
      Brand Family Calbiochem®
      SynonymsHuman ether-a-go-go related gene (hERG) K+ channel activator, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea, NS 1643, KV11.1 Channel Activator
      References
      ReferencesHansen, R., et al. 2006. Mol. Pharm. 69, 266.
      Schuster, A., et al. 2011. Mol. Pharm. 80, 930.
      Product Information
      CAS number448895-37-2
      FormOff-white powder
      Hill FormulaC₁₅H₁₀F₆N₂O₃
      Chemical formulaC₁₅H₁₀F₆N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freee (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      373501 0