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371964 HA 1004, Dihydrochloride

A cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A, CaM kinase II, myosin light chain kinase, protein kinase C.

HA 1004, Dihydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl

Primary Target: Protein kinase A
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      92564-34-6C₁₂H₁₅N₅O₂S · 2HCl
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A (Ki = 2.3 µM), CaM kinase II (Ki = 13 µM), myosin light chain kinase (Ki = 150 µM), protein kinase C (Ki = 40 µM), and protein kinase G (Ki = 1.3 µM). An intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
      Catalogue Number371964
      Brand Family Calbiochem®
      SynonymsN-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl
      References
      ReferencesCrowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
      Neveu, I., et al. 1992. Brain Res. 570, 316.
      Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
      Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
      Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.
      Product Information
      CAS number92564-34-6
      ATP CompetitiveY
      FormWhite powder
      Hill FormulaC₁₂H₁₅N₅O₂S · 2HCl
      Chemical formulaC₁₂H₁₅N₅O₂S · 2HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetProtein kinase A
      Primary Target K<sub>i</sub>2.3 µM against protein kinase A
      Purity>98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      371964 0

      Documentation

      HA 1004, Dihydrochloride MSDS

      Title

      Safety Data Sheet (SDS) 

      HA 1004, Dihydrochloride Certificates of Analysis

      TitleLot Number
      371964

      References

      Reference overview
      Crowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
      Neveu, I., et al. 1992. Brain Res. 570, 316.
      Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
      Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
      Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-November-2009 RFH
      SynonymsN-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl
      DescriptionA cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A (Ki = 2.3 µM), CaM kinase II (Ki = 13 µM), myosin light chain kinase (Ki = 150 µM), protein kinase C (Ki = 40 µM), and protein kinase G (Ki = 1.3 µM). An intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
      FormWhite powder
      CAS number92564-34-6
      Chemical formulaC₁₂H₁₅N₅O₂S · 2HCl
      Structure formulaStructure formula
      Purity>98% by TLC
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesCrowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
      Neveu, I., et al. 1992. Brain Res. 570, 316.
      Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
      Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
      Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.

      Related Products & Applications

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors