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345752 Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk

Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.

Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄

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345752
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₇₀H₁₂₃N₃O₃₀ · 2NH₄

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      Description
      OverviewHas been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
      Catalogue Number345752
      Brand Family Calbiochem®
      SynonymsNeu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
      References
      ReferencesDeMaria, R., et al. 1997. Science 277, 1652.
      Product Information
      FormWhite solid
      Hill FormulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
      Chemical formulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      345752-1MG 04055977193909

      Documentation

      Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk MSDS

      Title

      Safety Data Sheet (SDS) 

      Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk Certificates of Analysis

      TitleLot Number
      345752

      References

      Reference overview
      DeMaria, R., et al. 1997. Science 277, 1652.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-March-2008 JSW
      SynonymsNeu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
      DescriptionHas been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
      FormWhite solid
      Chemical formulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityChloroform:Methanol (2:1) or H₂O (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
      Toxicity Irritant
      ReferencesDeMaria, R., et al. 1997. Science 277, 1652.