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14-939 ErbB2, active

ErbB2, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-939
10 µg  Also available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.
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      Overview

      Replacement Information

      Special Offers

      This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
      Description
      Catalogue Number14-939
      Trade Name
      • Upstate
      DescriptionErbB2, active
      OverviewProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
      References
      Product Information
      PresentationProtein in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.5mM EDTA, 0.01% CHAPS, 50% glycerol, 2mM DTT. Frozen solution.
      Quality LevelMQ100
      Applications
      Key Applications
      • Kinase Assay
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • ERBB2
      • HER2
      • NGL
      • NEU
      • HER-2
      • TKR1
      • MLN19
      Protein TargetErbB2
      Purification MethodPurified using immobilized metal affinity chromatography.
      Target Sub-FamilyTK
      UniProt Number
      Molecular Weight69 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of poly(Glu, Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-939 04053252960864

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-939M ErbB2, active Show Pricing & Availability

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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases