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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
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508321
Sigma-AldrichDihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem
An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC₅₀ = 12 nM).
More>>An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC₅₀ = 12 nM). Less<<
Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
He, T. et al. 2013. Oncogene32, in press. Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett.16, 1610. Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents.38, 435. Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett.14, 1549. Allison, A., et al. 1993. Transplantation Proc.25, 67. Cramer, D. et al. 1992. Transplantation.53, 303.
He, T. et al. 2013. Oncogene32, in press. Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett.16, 1610. Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents.38, 435. Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett.14, 1549. Allison, A., et al. 1993. Transplantation Proc.25, 67. Cramer, D. et al. 1992. Transplantation.53, 303.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
96201-88-6
Chemical formula
C₂₃H₁₄F₂NNaO₂
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
He, T. et al. 2013. Oncogene32, in press. Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett.16, 1610. Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents.38, 435. Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett.14, 1549. Allison, A., et al. 1993. Transplantation Proc.25, 67. Cramer, D. et al. 1992. Transplantation.53, 303.