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268320 Daptomycin, Streptomyces sp. - CAS 103060-53-3 - Calbiochem

A semi-synthetic cyclic polypeptide antibiotic that is active against vancomycin-resistant gram-positive bacteria, including enterococci and Staphylococcus aureus (MIC₅₀ = 0.13 µg/ml).

Daptomycin, Streptomyces sp. - CAS 103060-53-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cubicin, Dapcin

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      103060-53-3C₇₂H₁₀₁N₁₇O₂₆
      Description
      OverviewA semi-synthetic cyclic polypeptide antibiotic that is active against vancomycin-resistant gram-positive bacteria, including enterococci and Staphylococcus aureus (MIC50 = 0.13 µg/ml). Its bactericidal activities have been attributed to its role in disruption of membrane potential and increased efflux of potassium ions from bacterial cells, which lead to disruption of protein, DNA, and RNA synthesis. Exhibits superior bactericidal properties compared to vancomycin (Cat. No. 627850) even in the presence of serum.
      Catalogue Number268320
      Brand Family Calbiochem®
      SynonymsCubicin, Dapcin
      References
      ReferencesKosmidis, C. and Levine, D.P., 2010. Expert Opin. Pharmacother. 11, 615.
      Cui, L., et al. 2006. Antimicrob. Agents Chemother. 50, 1079.
      Silverman, J.A., et al. 2003. Antimicrob. Agents Chemother. 47, 2538.
      Rybak, M.J., et al. 2000. Antimicrob. Agents Chemother. 44, 1062.
      Product Information
      CAS number103060-53-3
      FormOff-white to pale yellow solid
      Hill FormulaC₇₂H₁₀₁N₁₇O₂₆
      Chemical formulaC₇₂H₁₀₁N₁₇O₂₆
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      268320 0

      Documentation

      Daptomycin, Streptomyces sp. - CAS 103060-53-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Daptomycin, Streptomyces sp. - CAS 103060-53-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      268320

      References

      Reference overview
      Kosmidis, C. and Levine, D.P., 2010. Expert Opin. Pharmacother. 11, 615.
      Cui, L., et al. 2006. Antimicrob. Agents Chemother. 50, 1079.
      Silverman, J.A., et al. 2003. Antimicrob. Agents Chemother. 47, 2538.
      Rybak, M.J., et al. 2000. Antimicrob. Agents Chemother. 44, 1062.