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Buffer Detection Kit for Magnetic Beads
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324788
Sigma-AldrichDAPK Inhibitor - CAS 315694-89-4 - Calbiochem
The DAPK Inhibitor, also referenced under CAS 315694-89-4, controls the biological activity of DAPK.
More>>The DAPK Inhibitor, also referenced under CAS 315694-89-4, controls the biological activity of DAPK. Less<<
DAPK Inhibitor - CAS 315694-89-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
An oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 µM ATP), while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 µM.
Catalogue Number
324788
Brand Family
Calbiochem®
Synonyms
(4Z)-4-(3-Pyridylmethylene)-2-styryl-oxazol-5-one, Death-Associated Protein Kinase Inhibitor
DAPK Inhibitor - CAS 315694-89-4 - Calbiochem Certificates of Analysis
Title
Lot Number
324788
References
Reference overview
Okamoto, M., et al. 2009. J. Med. Chem.52, 7323.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
07-April-2011 RFH
Synonyms
(4Z)-4-(3-Pyridylmethylene)-2-styryl-oxazol-5-one, Death-Associated Protein Kinase Inhibitor
Description
An oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 µM ATP), while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 µM.
Form
Yellow solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
315694-89-4
Chemical formula
C₁₇H₁₂N₂O₂
Purity
≥95% by HPLC
Solubility
DMSO (25 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
