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239803 Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem

Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.

Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Shh Signaling Antagonist I

Primary Target: Hh signaling in Shh-light2 assay
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239803
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4449-51-8C₂₇H₄₁NO₂

Pricing & Availability

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239803-1MG
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      239803-5MG
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          Description
          OverviewA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10 mM solution in Ethanol (Cat. No. 239806).
          Catalogue Number239803
          Brand Family Calbiochem®
          SynonymsShh Signaling Antagonist I
          References
          ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
          Thayer, S.P., et al. 2003. Nature, 425, 851.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Product Information
          CAS number4449-51-8
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₇H₄₁NO₂
          Chemical formulaC₂₇H₄₁NO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetHh signaling in Shh-light2 assay
          Primary Target IC<sub>50</sub>20 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGY0750000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          239803-1MG 04055977198867
          239803-5MG 04055977198874

          Documentation

          Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          239803

          References

          Reference overview
          Berman, D.M., et al. 2003. Nature, 425, 846.
          Thayer, S.P., et al. 2003. Nature, 425, 851.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-October-2007 JSW
          SynonymsShh Signaling Antagonist I
          DescriptionA cell-permeable, steroidal alkaloid and cholesterol mimic that displays both teratogenic and anti-tumor properties. Disrupts cholesterol biosynthesis and specifically antagonizes shh (Sonic Hedgehog) signaling through direct interaction with Smo (smoothened), a protein that is related to G-protein-coupled receptors. Useful for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number4449-51-8
          RTECSGY0750000
          Chemical formulaC₂₇H₄₁NO₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (4 mg/ml), Ethanol (5 mg/ml), or DMF (10 mg/ml). Ethanol stock solutions may require warming to achieve complete solubilization.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
          Thayer, S.P., et al. 2003. Nature, 425, 851.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Incardona, J.P., et al. 1998. Development 125, 3553.