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239783 Cyclooxygenase Inhibitor Set - Calbiochem

The Cyclooxygenase Inhibitor Set controls the biological activity of Cyclooxygenase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Cyclooxygenase Inhibitor Set - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: COX-1
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      Overview

      Replacement Information
      Description
      OverviewContains 100 mg of Meloxicam (Cat. No. 444800), 5 mg of NS-398 (Cat. No. 349254), 5 mg of SC-560 (Cat. No. 565610), and 5 mg of Sulindac Sulfide (Cat. No. 574102).
      Catalogue Number239783
      Brand Family Calbiochem®
      References
      ReferencesFournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
      Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
      Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
      Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.
      Product Information
      FormSolid
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1
      Secondary targetCOX-2
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-42/43-63

      Harmful if swallowed.
      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      239783 0

      Documentation

      Cyclooxygenase Inhibitor Set - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Cyclooxygenase Inhibitor Set - Calbiochem Certificates of Analysis

      TitleLot Number
      239783

      References

      Reference overview
      Fournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
      Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
      Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
      Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2007 RFH
      DescriptionCyclooxygenases (COX) act on arachidonic acid to generate prostaglandins. They exist either as COX-1 or COX-2. COX-1, a constitutive enzyme associated with the endoplasmic reticulum, is responsible for maintaining normal physiologic function. It is found throughout the body, especially in the GI tract, kidneys, and platelets and its inhibition by NSAID is reported to cause GI damage, renal dysfunction, and platelet abnormalities. COX-2 is an inducible enzyme that is mainly associated with the nuclear envelope. It's activity is induced by several growth factors, cytokines, and inflammatory signals. COX-2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX-1 levels remain unchanged. Based on structural differences in the active sites of these isozymes, a new drug has been developed that specifically inhibits only the COX-2 activity. COX-2 inhibitors have the potential to provide the traditional benefits of NSAID with significantly reduced incidence of endoscopic ulcers. Hence, they offer greater therapeutic promise in the treatment of inflammation and cancer. This inhibitor set provides 4 inhibitors for testing the inhibitory effects on COX-1 and COX-2.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Multiple Toxicity Values, refer to MSDS
      ReferencesFournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
      Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
      Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
      Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.