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238590 Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem

Cucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.

Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: JSI-124, STAT3 Inhibitor XIV

Primary Target: JAK/STAT3
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238590
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2222-07-3C₃₀H₄₂O₇

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      Description
      OverviewA cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK.
      Catalogue Number238590
      Brand Family Calbiochem®
      SynonymsJSI-124, STAT3 Inhibitor XIV
      References
      ReferencesBlaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.
      Product Information
      CAS number2222-07-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₀H₄₂O₇
      Chemical formulaC₃₀H₄₂O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.
      Biological Information
      Primary TargetJAK/STAT3
      Primary Target IC<sub>50</sub>500 nM suppressing STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRC6200000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      238590-1MG 04055977216592

      Documentation

      Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      238590

      References

      Reference overview
      Blaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-April-2011 JSW
      SynonymsJSI-124, STAT3 Inhibitor XIV
      DescriptionA cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that exhibits anti-proliferative and anti-tumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/Signal transducer and activator of transcription 3 (Jak/STAT3) signaling pathway. Reported to suppress STAT3 tyrosine phosphorylation in v-src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Also shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt1, ERK1/2, or JNK.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2222-07-3
      RTECSRC6200000
      Chemical formulaC₃₀H₄₂O₇
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBlaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.