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234115
Sigma-AldrichColchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem
Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells.
More>>Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells. Less<<
Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
Catalogue Number
234115
Brand Family
Calbiochem®
References
References
Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189. Lindenboim, L., et al. 1995. J. Neurochem.64, 1054. Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929. Santell, L. 1992. Exp. Cell Res. 201, 358. Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.
Keep away from food, drink and animal feeding stuffs. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number
GTIN
234115-1GM
07790788048839
234115-5GM
07790788048846
Documentation
Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem MSDS
Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem Certificates of Analysis
Title
Lot Number
234115
References
Reference overview
Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189. Lindenboim, L., et al. 1995. J. Neurochem.64, 1054. Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929. Santell, L. 1992. Exp. Cell Res. 201, 358. Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
22-October-2009 RFH
Description
Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
Form
Yellow or off-white powder
CAS number
64-86-8
RTECS
GH0700000
Chemical formula
C₂₂H₂₅NO₆
Structure formula
Purity
≥94% by HPLC
Solubility
Ethanol (10 mg/ml) or H₂O
Storage
Protect from light
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 2471
References
Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189. Lindenboim, L., et al. 1995. J. Neurochem.64, 1054. Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929. Santell, L. 1992. Exp. Cell Res. 201, 358. Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.
