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219465 Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem

A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties.

Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX

Primary Target: 20S proteasome
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219465
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Overview

Key Spec Table

CAS #Empirical Formula
34157-83-0C₂₉H₃₈O₄

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219465-10MG
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      Description
      OverviewA cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PGE2, and 210 nM for IL-8 and TNF-α), as well as LPS-induced NF-κB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Has also been shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Significantly improves the performance in memory, learning, and psychomotor activity in rats. May be useful to minimize inflammation in Alzheimer′s disease (AD).
      Catalogue Number219465
      Brand Family Calbiochem®
      SynonymsTripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
      References
      ReferencesYang, H., et al. 2006. Cancer Res. 66, 4758.
      Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
      Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
      Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
      He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
      Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.
      Product Information
      CAS number34157-83-0
      ATP CompetitiveN
      FormRed crystals
      Hill FormulaC₂₉H₃₈O₄
      Chemical formulaC₂₉H₃₈O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target20S proteasome
      Primary Target IC<sub>50</sub>2.5 µM inhibiting chymotrypsin-like activity of 20S proteasome
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      219465-10MG 04055977218459