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219457 Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

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219457
  
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      471270-60-7C₁₈H₂₄N₆O₂
      Description
      Overview

      This product has been discontinued.



      An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.

      Catalogue Number219457
      Brand Family Calbiochem®
      Synonyms2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
      References
      ReferencesVermeulen, K., et al. 2002. Leukemia 16, 299.
      Product Information
      CAS number471270-60-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₂₄N₆O₂
      Chemical formulaC₁₈H₂₄N₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCDK1, CDK2
      Primary Target IC<sub>50</sub>100 nM, 80 nM, against Cdk1 and Cdk2, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      219457 0