219457 Sigma-AldrichCdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem
Synonyms: 2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine
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Overview
Key Spec Table
CAS # | Empirical Formula |
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471270-60-7 | C₁₈H₂₄N₆O₂ |
Description | |
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Overview | This product has been discontinued. An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition. |
Catalogue Number | 219457 |
Brand Family | Calbiochem® |
Synonyms | 2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine |
References | |
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References | Vermeulen, K., et al. 2002. Leukemia 16, 299. |
Product Information | |
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CAS number | 471270-60-7 |
ATP Competitive | N |
Form | Yellow solid |
Hill Formula | C₁₈H₂₄N₆O₂ |
Chemical formula | C₁₈H₂₄N₆O₂ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | CDK1, CDK2 |
Primary Target IC<sub>50</sub> | 100 nM, 80 nM, against Cdk1 and Cdk2, respectively |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | N |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
219457 | 0 |