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219401 Cathepsin D, Human Liver

Cathepsin D, Human Liver, CAS 9025-26-7, is a purified native cathepsin D from human liver. Overexpression of cathepsin D in is associated with higher risk of cancer relapse and metastasis.

Cathepsin D, Human Liver MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
219401
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Overview

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219401-15U
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      219401-30U
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          Description
          OverviewNative cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
          Catalogue Number219401
          Brand Family Calbiochem®
          References
          ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
          Barbi, G.P., et al. 1994. Oncology 51, 329.
          Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
          Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
          Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
          Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
          Erickson, A. 1989. J. Cell. Biochem. 40, 31.
          Product Information
          CAS number9025-26-7
          Unit of DefinitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
          EC number3.4.23.5
          FormLyophilized
          FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥300 units/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          219401-15U 04055977201710
          219401-30U 04055977201727

          Documentation

          Cathepsin D, Human Liver Certificates of Analysis

          TitleLot Number
          219401

          References

          Reference overview
          Berchem, G., et al. 2002. Oncogene 21, 5951.
          Barbi, G.P., et al. 1994. Oncology 51, 329.
          Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
          Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
          Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
          Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
          Erickson, A. 1989. J. Cell. Biochem. 40, 31.

          Brochure

          Title
          Cathepsins and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionNative cathepsin D from human liver. Degrades the extracellular matrix and releases growth factors bound to the matrix. Overexpression of cathepsin D in human breast cancers is associated with a higher risk of relapse and metastasis.
          FormLyophilized
          FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
          SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9025-26-7
          EC number3.4.23.5
          Purity≥90% by SDS-PAGE
          Specific activity≥300 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
          SolubilitySterile H₂O or aqueous buffers. Please see vial label for lot-specific reconstitution volume.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
          Toxicity Standard Handling
          Merck USA index14, 1905
          ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
          Barbi, G.P., et al. 1994. Oncology 51, 329.
          Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
          Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
          Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
          Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
          Erickson, A. 1989. J. Cell. Biochem. 40, 31.