504041 Sigma-AldrichCaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem
Synonyms: CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV, (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR
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Overview
Key Spec Table
CAS # | Empirical Formula |
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3562-84-3 | C₁₇H₁₂Br₂O₃ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.04041.0001 |
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Botol kaca | 100 mg |
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Description | |
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Overview | A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat. No. 481987) and NPPB (Cat. No. 484100) in suppressing 500 nM Ionomycin- (Cat. Nos. 407950, 407952, and 407953) induced I- influx in TMEM16A-expressing HEK293 cells (IC50 = 9.97, 140, and 150 µM, respectively) as well as in blocking voltage-gated Cl- current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR. Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation. |
Catalogue Number | 504041 |
Brand Family | Calbiochem® |
Synonyms | CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV, (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR |
Product Information | |
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CAS number | 3562-84-3 |
Form | White powder |
Hill Formula | C₁₇H₁₂Br₂O₃ |
Chemical formula | C₁₇H₁₂Br₂O₃ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | TMEM16A-CaCC |
Purity | ≥97% by HPLC |
Safety Information | |
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R Phrase | R: 25 Toxic if swallowed. |
S Phrase | S: 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
5.04041.0001 | 04055977264234 |