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534363 CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem

A 11-mer peptide that mimics CTNF action and rescues autism sera-induced cell death and oxidative stress in cultured cortical neurons. Exerts its neuroprotective effect by enhancing BDNF expression.

CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ciliary Neurotrophic Factor Epitope Peptide 6

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534363
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1312886-56-8C₅₅H₉₀N₁₄O₁₆

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      Description
      OverviewA brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number534363
      Brand Family Calbiochem®
      SynonymsCiliary Neurotrophic Factor Epitope Peptide 6
      DescriptionCNTF Mimetic, P6 Peptide
      References
      ReferencesKazim, S., et al. 2015. Plos One. 10, e0118627.
      Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
      Li, B., et al. 2010. FEBS Lett. 584,3359.
      Product Information
      CAS number1312886-56-8
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₅H₉₀N₁₄O₁₆
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-VGDGGLFEKKL-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.34363.0001 04054839117169

      Documentation

      CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      534363

      References

      Reference overview
      Kazim, S., et al. 2015. Plos One. 10, e0118627.
      Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
      Li, B., et al. 2010. FEBS Lett. 584,3359.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-November-2016 JSW
      SynonymsCiliary Neurotrophic Factor Epitope Peptide 6
      DescriptionA brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1312886-56-8
      Peptide SequenceAc-VGDGGLFEKKL-NH₂
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml) or H₂O (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKazim, S., et al. 2015. Plos One. 10, e0118627.
      Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
      Li, B., et al. 2010. FEBS Lett. 584,3359.