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196418 BAPTA, Tetrasodium Salt

Ca2+ chelator exhibiting a 105-fold greater affinity for Ca2+ .

BAPTA, Tetrasodium Salt MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na

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196418
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
126824-24-6C₂₂H₂₀N₂O₁₀ · 4Na

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      Description
      OverviewCa2+ chelator exhibiting a 105-fold greater affinity for Ca2+ (Kd = 110 nM) than for Mg2+. After BAPTA complexes with Ca2+, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca2+ levels, especially transient phenomena, because of its insensitivity to pH. Useful for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.
      Catalogue Number196418
      Brand Family Calbiochem®
      Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
      References
      ReferencesDeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Li, L., et al. 1995. J. Cell Physiol. 163, 105.
      Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.
      Product Information
      CAS number126824-24-6
      FormWhite to off-white solid
      Hill FormulaC₂₂H₂₀N₂O₁₀ · 4Na
      Chemical formulaC₂₂H₂₀N₂O₁₀ · 4Na
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      196418-1GM 04055977206470

      Documentation

      BAPTA, Tetrasodium Salt MSDS

      Title

      Safety Data Sheet (SDS) 

      BAPTA, Tetrasodium Salt Certificates of Analysis

      TitleLot Number
      196418

      References

      Reference overview
      DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Li, L., et al. 1995. J. Cell Physiol. 163, 105.
      Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-August-2019 JSW
      Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
      DescriptionCa2+-chelator exhibiting a 105-fold greater affinity for Ca2+ (110 nM) than for Mg2+. After BAPTA complexes with Ca2+, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca2+ levels, especially transient phenomena, because of its insensitivity to pH. Has been used for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.
      FormWhite to off-white solid
      CAS number126824-24-6
      Chemical formulaC₂₂H₂₀N₂O₁₀ · 4Na
      Structure formulaStructure formula
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesDeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
      Li, L., et al. 1995. J. Cell Physiol. 163, 105.
      Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Chelating Agents