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189490 Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem

Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.

Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Methyladenine

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189490
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
5142-23-4C₆H₇N₅

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      189490-50MG
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          Description
          OverviewA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
          Catalogue Number189490
          Brand Family Calbiochem®
          Synonyms3-Methyladenine
          References
          ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
          Product Information
          CAS number5142-23-4
          FormWhite to faint yellow powder
          Hill FormulaC₆H₇N₅
          Chemical formulaC₆H₇N₅
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationAutophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          189490-100MG 04055977221831
          189490-50MG 07790788048235

          Documentation

          Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          189490

          References

          Reference overview
          Canu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-May-2012 JSW
          Synonyms3-Methyladenine
          DescriptionA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
          FormWhite to faint yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5142-23-4
          Chemical formulaC₆H₇N₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or H₂O (5 mg/ml). In applications where high working concentrations are necessary (e.g. 10 mM), the use of a pre-made stock solution may result in the introduction of higher than desired solvent (e.g., DMSO) into the experimental systems. In such cases, it is recommended that the solid compound be weighed out at the time of use and reconstituted directly into the solutions used in the experimental system (buffers, media, etc.). Vortexing may be required for complete solubilization in water.
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.