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582000 Anti-Telomerase (Ab-1) Rabbit pAb

This Anti-Telomerase (Ab-1) Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation, Paraffin Sections for the detection of Telomerase (Ab-1).

Anti-Telomerase (Ab-1) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-TERT-1

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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      H, MRbPolyclonal Antibody
      Description
      OverviewRecognizes the ~125 kDa telomerase (TERT) protein.
      Catalogue Number582000
      Brand Family Calbiochem®
      SynonymsAnti-TERT-1
      References
      ReferencesFu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
      Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
      Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.
      Product Information
      FormLiquid
      FormulationUndiluted serum.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunoprecipitation
      Paraffin Sections
      Application NotesImmunoblotting (1:100, see comments)
      Immunoprecipitation (1:40, see comments)
      Paraffin Sections (1:250-1:1000, see comments)
      Application CommentsAntibody works only weakly in paraffin-embedded tissue sections. Nuclear extracts are recommended for immunoblotting and immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids from an internal region of the catalytic subunit of human telomerase reverse transcriptase (hTERT)
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      582000 0

      Documentation

      Anti-Telomerase (Ab-1) Rabbit pAb MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Telomerase (Ab-1) Rabbit pAb Certificates of Analysis

      TitleLot Number
      582000

      References

      Reference overview
      Fu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
      Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
      Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-September-2007 JSW
      SynonymsAnti-TERT-1
      ApplicationImmunoblotting (1:100, see comments)
      Immunoprecipitation (1:40, see comments)
      Paraffin Sections (1:250-1:1000, see comments)
      DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~125 kDa telomerase (TERT) protein.
      BackgroundThe 3' ends of chromosomes are capped with telomere sequences (TTAGGG; 6-26 nucleotides in length) by ribonucleo-protein telomerase during DNA replication. Telomerase is an unusual RNA-dependent DNA polymerase that uses an RNA component to specify the addition of telomere. In ciliated protozoa and yeast, telomere length is maintained by regulating the activity of telomerase. Many mammalian cells do not express telomerase, resulting into shortening of the telomere with each cell division, ultimately causing chromosomal instability, aging and cell death. ~4.8 kb of telomeric DNA is lost with each cell division. Most recently, introduction of telomerase into normal human cells has been shown to extend normal cell life by ~20 doublings.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids from an internal region of the catalytic subunit of human telomerase reverse transcriptase (hTERT)
      IsotypeIgG
      Specieshuman, mouse
      FormLiquid
      FormulationUndiluted serum.
      PreservativeNone
      CommentsAntibody works only weakly in paraffin-embedded tissue sections. Nuclear extracts are recommended for immunoblotting and immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesFu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
      Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
      Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.