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MABN390 Anti-Sigma IR Antibody, clone ICR-SIG1R-A

Detect the Sigma IR protein using this Anti-Sigma IR, clone ICR-SIG1R-A validated for use in wb, IP, ICC, Flow & IHC.

Anti-Sigma IR Antibody, clone ICR-SIG1R-A MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SIGMAR1, OPRS1, SRBP UniProt Number: Q99720
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MABN390
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IP, ICC, FC, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN390
      DescriptionAnti-Sigma IR Antibody, clone ICR-SIG1R-A
      Alternate Names
      • Sigma non-opioid intracellular receptor 1
      • Sigma 1-type opioid receptor
      • Sigma1-receptor
      • Sigma1R
      Background InformationSigma1R, or Sigma non-opioid intracellular receptor 1, is part of the ERG2 family that forms a ternary complex with ANK2 and ITPR3. Sigma1R is involved in lipid transport from the endoplasmic reticulum, BDNF and EGF signaling, potassium ion channel regulation and other cell functions including apoptosis, survival and proliferation. It was initially discovered through its binding to various psychoactive drugs, and has been studied in memory, learning and mood alteration processes. Sigma1R is often found in the nuclear membrane, synapses and endoplasmic reticulum of cells within liver, brain, kidney and thymus tissues.
      References
      Product Information
      FormatPurified
      Control
      • Colo-587 cell lysate
      PresentationPurified rat monoclonal IgG2c in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the Sigma IR protein using this Anti-Sigma IR, clone ICR-SIG1R-A validated for use in wb, IP, ICC, Flow & IHC.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesImmunoprecipitation Analysis: A representative lot was used by an an independent laboratory to detect Sigma IR in certain cancer cell lysates.
      Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect Sigma IR in human cancer cells including pancreatic carcinoma and sarcoma cell lines and xenografts.
      Flow Cytometry Analysis: A representative lot was used by an an independent laboratory to detect Sigma IR in tumor cells.
      Immunohistochemistry Analysis: A representative lot was used by an an independent laboratory to detect Sigma IR in human cancer cells including pancreatic carcinoma and sarcoma cell lines and xenografts.
      Biological Information
      ImmunogenLinear peptide corresponding to human Sigma IR.
      CloneICR-SIG1R-A
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2c
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Mouse based upon immunogen design.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SIGMAR1
      • OPRS1
      • SRBP
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~25 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing at ~25 kDa, ~23 kDa, ~21.5 kDa, ~12 kDa and ~21 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in colo-587 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Sigma IR in 10 µg of colo-587 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN390 04053252855573

      Documentation

      Anti-Sigma IR Antibody, clone ICR-SIG1R-A MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Sigma IR Antibody, clone ICR-SIG1R-A Certificates of Analysis

      TitleLot Number
      Anti-Sigma IR, clone ICR-SIG1R-A - Q2139341 Q2139341
      Anti-Sigma IR, clone ICR-SIG1R-A - 2561729 2561729
      Anti-Sigma IR, clone ICR-SIG1R-A - 3221966 3221966
      Anti-Sigma IR, clone ICR-SIG1R-A - 3291280 3291280
      Anti-Sigma IR, clone ICR-SIG1R-A - 3387600 3387600
      Anti-Sigma IR, clone ICR-SIG1R-A - 3482788 3482788
      Anti-Sigma IR, clone ICR-SIG1R-A -2548722 2548722
      Anti-Sigma IR, clone ICR-SIG1R-A -2608854 2608854
      Anti-Sigma IR, clone ICR-SIG1R-A -2712569 2712569
      Anti-Sigma IR, clone ICR-SIG1R-A -2743583 2743583
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