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MABN621 Anti-Pan-Neurofascin Antibody, clone L11A/41

Detect Neurofascin using this mouse monoclonal antibody, Anti-Pan-Neurofascin Antibody, clone L11A/41 validated for use in western blotting & IHC.

Anti-Pan-Neurofascin Antibody, clone L11A/41 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Nfasc UniProt Number: P97685
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MABN621
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN621
      DescriptionAnti-Pan-Neurofascin Antibody, clone L11A/41
      Alternate Names
      • Neurofascin
      Background InformationNeurofascin is a ankyrin binding protein that may be involved in myelination, neurite extension, synaptogenesis, axonal guidance and neuron-glial cell interactions. There are two known isoforms, NF155 and NF186. NF155 is found in oligodendrocytes, and is involved in neurite outgrowth and neuronal adhesion. NF186 is expressed in neurons, and may optimize communication between neurons by anchoring the axon initial segment (AIS).
      References
      Product Information
      FormatPurified
      Control
      • Rat brain tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Neurofascin using this mouse monoclonal antibody, Anti-Pan-Neurofascin Antibody, clone L11A/41 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pan-Neuorfascin in rat pons tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to rat Pan-Neurofascin.
      CloneL11A/41
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      Species Reactivity NoteDemonstrated to react with Rat. Other Homologies: Human (99% sequence homology).
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Nfasc
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~185 kDa and ~155 kDa observed. Three isoforms are known to exist at 138 kDa, 134 kDa, and 132 kDa due to alternative splicing. This protein has been observed at ~186 kDa, ~180 kDa, ~166 kDa and ~155 kDa (Kriebel, M., et al. (2012). Int J Biochem Cell Biol. 44(5):694-697.). This protein may undergo post-translational modification.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Pan-Neurofascin in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN621 04053252896781