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PC152 Anti-Pan β-Amyloid (1-40) Rabbit pAb

Anti-Pan β-Amyloid (1-40) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC152
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes all three β-amyloid peptides, Aβ40, Aβ42, and Aβ43.
    • Antibody Target Gene Symbol: APP
    • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
    • Entrez Gene Name: amyloid beta (A4) precursor protein
    • Hu Entrez ID: 351 (Related Antibodies: 171610, PC729,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
    • Mu Entrez ID: 11820
    • Rat Entrez ID: 54226
      		•
      Catalogue NumberPC152
      Brand Family Calbiochem®
      References
      ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
      Borchelt, D.R., et al. 1997. Neuron 19, 939.
      Citron, M., et al. 1997. Nature Med. 3, 67.
      Hardy, J. 1997. Trends in Neurosci. 20, 154.
      Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
      Duff, K., et al. 1996. Nature 383, 710.
      Iwatsubo, T., et al. 1994. Neuron 13, 45.
      Suzuki, N., et al. 1994. Science 264, 133.
      Product Information
      FormLiquid
      FormulationIn PBS.
      PreservativeNone
      Applications
      Key Applications Dot Blot
      Enzyme-Linked Immunosorbent Assay
      Immunohistochemistry
      Radioimmunoassay
      Application NotesDot Blot (see comments)
      ELISA (1 µg/ml)
      Immunohistochemistry (see comments)
      Radioimmunoassay (see comments)
      Application CommentsThis antibody is not blocked by β-amyloid peptide [1-12] whereas, β-amyloid peptide [14-35], β-amyloid peptide [15-28], β-amyloid peptide [17-30] and β-amyloid peptide [1-40] were all able to block antibody activity. This antibody is also reported to work for dot blots, immunohistochemistry, and radioimmunoassay. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids 1-40 of human Aβ₁₋₄₀ peptide
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C)
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC152 0

      Documentation

      Anti-Pan β-Amyloid (1-40) Rabbit pAb MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Pan β-Amyloid (1-40) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC152

      References

      Reference overview
      Savage, M.J., et al. 1998. J. Neurosci. 15, 1743.
      Borchelt, D.R., et al. 1997. Neuron 19, 939.
      Citron, M., et al. 1997. Nature Med. 3, 67.
      Hardy, J. 1997. Trends in Neurosci. 20, 154.
      Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
      Duff, K., et al. 1996. Nature 383, 710.
      Iwatsubo, T., et al. 1994. Neuron 13, 45.
      Suzuki, N., et al. 1994. Science 264, 133.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-February-2012 JSW
      ApplicationDot Blot (see comments)
      ELISA (1 µg/ml)
      Immunohistochemistry (see comments)
      Radioimmunoassay (see comments)
      DescriptionProtein G purified rabbit polyclonal antibody. Recognizes Aβ1-40, Aβ1-42, and Aβ1-43.
      BackgroundA number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer's Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing of βAPP, resulting in increased extracellular concentration of β-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of Aβ leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recognizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin and βAPP mutants while other studies have used Aβ specific antibodies to prevent the in vitro fibrillar aggregation of Aβ.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids 1-40 of human Aβ₁₋₄₀ peptide
      IsotypeIgG
      Specieshuman
      FormLiquid
      FormulationIn PBS.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsThis antibody is not blocked by β-amyloid peptide [1-12] whereas, β-amyloid peptide [14-35], β-amyloid peptide [15-28], β-amyloid peptide [17-30] and β-amyloid peptide [1-40] were all able to block antibody activity. This antibody is also reported to work for dot blots, immunohistochemistry, and radioimmunoassay. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C)
      Toxicity Standard Handling
      ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
      Borchelt, D.R., et al. 1997. Neuron 19, 939.
      Citron, M., et al. 1997. Nature Med. 3, 67.
      Hardy, J. 1997. Trends in Neurosci. 20, 154.
      Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
      Duff, K., et al. 1996. Nature 383, 710.
      Iwatsubo, T., et al. 1994. Neuron 13, 45.
      Suzuki, N., et al. 1994. Science 264, 133.