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MABF3077-25UG Anti-MALT1 Antibody, clone 17C11

This rat monoclonal Anti-MALT1, clone 17C11, Cat. No. MABF3077 is tested for use in Western Blotting and Immunoprecipitation, for the detection of MALT1.

NewMABF3077-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF3077-25UG
      DescriptionAnti-MALT1 Antibody, clone 17C11
      Alternate Names
      • MALT lymphoma-associated translocation
      • Paracaspase
      • MLT
      Background InformationMucosa-associated lymphoid tissue lymphoma translocation protein 1 (Uniprot: Q9UDY8; also known as MALT lymphoma-associated translocation) is encoded by MALT1 (MLT) gene (Gene ID:10892 ) in human. MALT1 protein shuttles between the nucleus and cytoplasm and also found in perinuclear structures. It is highly expressed in peripheral blood mononuclear cells and detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. MALT1 is a key regulator of various cellular signaling pathways and is primarily associated with immune response and inflammation. Bcl10 and MALT1 (paracaspase) forms a strong and specific complex within the cell and these proteins synergize in the activation of NF-kappaB pathway, which is involved in the regulation of genes related to immune and inflammatory responses. MALT1 is also implicated in the pathogenesis of certain lymphomas and autoimmune diseases, making it a potential target for therapeutic interventions. Its proteolytic activity and interactions with other proteins contribute to its multifaceted functions in cellular signaling and disease processes. (Ref.: Kutzner, K., et al. (2022). Sci Signal. 15(723):eabk3083; Lucas, et al. (2001). J Biol Chem. 276(22);19012-9.)
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationThis rat monoclonal Anti-MALT1, clone 17C11, Cat. No. MABF3077 is tested for use in Western Blotting and Immunoprecipitation, for the detection of MALT1.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesTested Applications

      Immunoprecipitation Analysis: A representative lot immunoprecipitated MALT1 in Immunoprecipitation application (Kutzner, K., et al. (2022). Sci Signal. 15(723):eabk3083).

      Western Blotting Analysis: A representative lot detected MALT1 in Western Blotting application (Kutzner, K., et al. (2022). Sci Signal. 15(723):eabk3083).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenHis-tagged recombinant fragment corresponding to 380 amino acids from the internal region of human MALT1 protein.
      EpitopeUnknown
      Clone17C11
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostRat
      SpecificityClone 17C11 is a rat monoclonal antibody that specifically detects MALT1 protein. It targets an epitope within 380 amino acids from the internal region of the protein.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MLT
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight ~ 92 kDa observed, 92.72 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in lysates from Jurkat cells and Jurkat cells with MALT1 Knock out. lysates.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected MALT1 in Jurkat cell lysate, but not in lysates from cells with MALT1 knockout.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF3077-25UG 04065271270237