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MABS451 Anti-Linear Ubiquitin Antibody, clone LUB9

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MABS451
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS451
      DescriptionAnti-Linear Ubiquitin Antibody, clone LUB9
      Alternate Names
      • Polyubiquitin-C
      • Ubiquitin
      Background InformationUbiquitin functions as a marker to indicate the fate of other proteins in the cell. It can be attached as a single molecule or as a polyubiquitin chain. Although ubiquitinated proteins are oftentimes tagged for degradation by the 20S proteosome, ubiquitination can also indicate alternative fates depending on the lysine residue that is involved in linking the ubiquitin chain to the target protein. Ubiquitin chains linked by Lys33 to kinase substrates such as AMP-activated protein kinases, (AMPKα1, BRSK1, MARK3, MARK4, and NUAK1), may activate or deactivate these proteins, supporting the role for uniquitin in regulating signaling.
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Linear Ubiquitin Antibody, clone LUB9 | MABS451 is an antibody against Linear Ubiquitin Antibody for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected Linear Ubiquitin in (M1-linked) ubiquitin chains (Yoshiteru, S. et al. (2013). EMBO. 32:2463-2476).
      Biological Information
      ImmunogenOvalbumin-conjugated linear peptide corresponding to human Linear Ubiquitin.
      CloneLUB9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityThis antibody detects only Linear Ubiquitin.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • UBC
      Purification MethodProtein G Purified
      UniProt Number
      Molecular WeightMultiple bands observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in recombinant protein Linear Polyubiquitin chains, K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected 10 µg of Linear Polyubiquitin recombinant protein chains, bands were not detected in K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MABS451 04055977125375