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IM55 Anti-Cathepsin K Mouse mAb (182-12G5)

Anti-Cathepsin K Mouse mAb (182-12G5) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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IM55
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      HMMonoclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the ~28 kDa cathepsin K protein in human osteoclasts.
      Catalogue NumberIM55
      Brand Family Calbiochem®
      References
      ReferencesInaoka, T., et al. 1995. Biochem. Biophys. Res. Commun. 206, 89.
      Tezuka, K., et al. 1994. J. Biol. Chem. 269, 1106.
      Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol. 80, 535.
      Product Information
      DeclarationManufactured by Daiichi Fine Chemical Co., Ltd. Not available for sale in Japan.
      FormLiuid
      FormulationIn 100 mM sodium phosphate buffer, 0.1% BSA, pH 7.0
      Positive controlOsteoclasts
      Preservative≤0.1% sodium azide
      Quality LevelMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (5 µg/ml)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K
      ImmunogenHuman
      Clone182-12G5
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      IM55 0

      Documentation

      Anti-Cathepsin K Mouse mAb (182-12G5) MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Cathepsin K Mouse mAb (182-12G5) Certificates of Analysis

      TitleLot Number
      IM55

      References

      Reference overview
      Inaoka, T., et al. 1995. Biochem. Biophys. Res. Commun. 206, 89.
      Tezuka, K., et al. 1994. J. Biol. Chem. 269, 1106.
      Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol. 80, 535.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2009 JSW
      ApplicationImmunoblotting (5 µg/ml)
      DescriptionPurified mouse monoclonal antibody (see application references). Recognizes the ~28 kDa cathepsin K protein.
      BackgroundCathepsins are normal lysosomal proteases, which are expressed in all cells where they function in protein turnover. They have also been shown to be capable of degrading extracellular matrix proteins. Cathepsin K, also known as OC-2, is a cysteine endoproteinase that is predominantly expressed in osteoclasts and is structurally and functionally related to cathepsin L and cathepsin S. The cloned human cDNA encodes a protein of 329 amino acids showing a 94% homology to rabbit cathepsin K. Northern blot analysis show elevated levels of cathepsin K mRNA in osteoarthritic hip bones and very high levels in osteoclastoma compared to low levels in other tissues such as kidney, liver, spleen and lung. The predominant expression of cathepsin K in osteoclasts suggests an important role in human osteoclastic bone resorption and may provide possible rationale for the treatment of osteoporosis and certain forms of arthritis.
      HostMouse
      Immunogen speciesHuman
      Immunogena synthetic peptide (SEDAYPYVGQEESC) corresponding to amino acids 182-195 of human cathepsin K
      Clone182-12G5
      IsotypeIgG₁
      Specieshuman
      Positive controlOsteoclasts
      FormLiuid
      FormulationIn 100 mM sodium phosphate buffer, 0.1% BSA, pH 7.0
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesInaoka, T., et al. 1995. Biochem. Biophys. Res. Commun. 206, 89.
      Tezuka, K., et al. 1994. J. Biol. Chem. 269, 1106.
      Barrett, A.J. and Kirschke, H. 1981. Meth. Enzymol. 80, 535.