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ABT267 Anti-CELSR3 Antibody

Detect CELSR3 using this rabbit polyclonal antibody, Anti-CELSR3 Antibody validated for use in IHC.

Anti-CELSR3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: CELSR3, CDHF11, EGFL1, FMI1, MEGF2 UniProt Number: Q9NYQ7
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ABT267
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT267
      DescriptionAnti-CELSR3 Antibody
      Alternate Names
      • Cadherin EGF LAG seven-pass G-type receptor 3
      • Cadherin family member 11
      • Epidermal growth factor-like protein 1
      • EGF-like protein 1
      • Flamingo homolog 1
      • hFmi1
      • Multiple epidermal growth factor-like domains protein 2

      • Short name=Multiple EGF-like domains protein 2
      Background InformationCELSR3, also known as Cadherin family member 11, Epidermal growth factor-like protein 1, EGF-like protein 1 or Flamingo homolog 1, FML1, or Multiple epidermal growth factor like domains protein 2, and encoded by the gene CELSR3/CDHF11, EGFL1, FMI1, KIAA0812, MEGF2, is a cell surface receptor important for cell to cell signaling and positioning particularly during the development of the nervous system. It is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined but may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation, and recent research demonstrates that CELSR3 is critical for proper development of GABA-signaling pathways in the inner retina. As a cadherin member, CELSR3 is localized to the cell membrane.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect CELSR3 using this rabbit polyclonal antibody, Anti-CELSR3 Antibody validated for use in IHC.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain within the C-terminus of human CELSR3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CELSR3
      • CDHF11
      • EGFL1
      • FMI1
      • MEGF2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight358 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebellum and glioma sections.

      Immunohistochemistry Analysis: A 1:2000 dilution and a 1:500 dilution of this antibody detected CELSR3 in human cerebellum and glioma sections, respectively.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABT267 04053252935947