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MABS385 Anti-APOL1 Antibody, clone 1D4

Detect Apolipoprotein using this mouse monoclonal antibody, Anti-APOL1 Antibody & clone 1D4 validated for use in western blotting.

Anti-APOL1 Antibody, clone 1D4 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: APOL, APO-L, APOL-I UniProt Number: O14791
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MABS385
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABS385
      DescriptionAnti-APOL1 Antibody, clone 1D4
      Alternate Names
      • APOL
      • APO-L
      • APOL-I
      • Apolipoprotein L1
      • Apolipoprotein L
      • Apolipoprotein L-I
      Background InformationApolipoprotein L1/Apolipoprotein L-1 (ApoL-1), or alternatively Apolipoprotein L (Apo-L/ApoL) is the protein encoded by the APOL1 gene in humans. Apolipoprotein L1 is one of the major carriers of cholesterol in the blood. It plays a role in the transport of cholesterol from the peripheral cells to the liver. It is a secreted protein expressed in liver, pancreas, lung, prostate, placenta and spleen. Apolipoprotein L1 is part of the HDL (high density lipoprotein) complex and Apolipoprotein L1 possesses both extra- and intra-cellular functions crucial in host defense and cellular homeostatic mechanisms. Alterations in Apolipoprotein L1 function due to genetic, environmental, and lifestyle factors have been associated with African sleeping sickness, atherosclerosis, lipid disorders, obesity, schizophrenia, cancer, and chronic kidney disease (CKD), yet much of its biological function remains unknown. Interesting, Apolipoprotein L1 has the ability to kill circulating trypanosomes in the blood. Trypanosomes cause a serious disease called sleeping sickness but in those individuals that have particular splice variants of Apolipoprotein L1 are spared sleeping sickness, however the variants are associated with an increased chance of kidney disease as a tradeoff. Apolipoprotein L1 appears important in autophagy and even as a cancer preventative as well. Recent research shows that increased intracellular levels of Apolipoprotein L1 can induce autophagy and autophagy-associated cell death but that Apolipoprotein L1 may protect kidney cells against renal cell carcinoma.
      References
      Product Information
      FormatAscites
      Control
      • Human plasma lysate
      PresentationMouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Apolipoprotein using this mouse monoclonal antibody, Anti-APOL1 Antibody & clone 1D4 validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPurified recombinant fragment of human APOL1 expressed in E. Coli.
      Clone1D4
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • APOL
      • APO-L
      • APOL-I
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~44 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human plasma.

      Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected APOL1 in human plasma.

      Optimal working dilutions must be determined by end user.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS385 04053252918186