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171260 AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC₅₀ = 25.1, 148, and 234.6 nM, respectively).

AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I

Primary Target: AMPK
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171260
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Overview

Key Spec Table

CAS #Empirical Formula
866405-64-3C₂₄H₂₅N₅O

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171260-10MG
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      171260-1MG
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              Description
              OverviewA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
              Catalogue Number171260
              Brand Family Calbiochem®
              Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
              References
              ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
              Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
              Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
              Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
              Inoki, K., et al. 2003. Cell 115, 577.
              Fryer, L.G., 2002. FEBS Lett. 531, 189.
              Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
              Product Information
              CAS number866405-64-3
              ATP CompetitiveY
              FormLight yellow solid
              Hill FormulaC₂₄H₂₅N₅O
              Chemical formulaC₂₄H₂₅N₅O
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Biological Information
              Primary TargetAMPK
              Primary Target IC<sub>50</sub>25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
              Primary Target K<sub>i</sub>EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Storage and Shipping Information
              Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Global Trade Item Number
              Catalogue Number GTIN
              171260-10MG 04055977207156
              171260-1MG 04055977207149
              171260-5MG 04055977207163