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658402 AG 527

AG 527 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)

658402
  
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      Overview

      Description
      OverviewA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 2.5 µM). Also inhibits phosphorylation of poly-GAT by the EGF receptor (IC50 = 400 nM).
      Catalogue Number658402
      Brand Family Calbiochem®
      Synonyms(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)
      References
      ReferencesGazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Product Information
      CAS number133550-32-0
      FormYellow solid
      Hill FormulaC₁₈H₁₆N₂O₃
      Chemical formulaC₁₈H₁₆N₂O₃
      Structure formula ImageStructure formula Image
      Biological Information
      Primary Targetepidermal growth factor (EGF) receptor kinase autophosphorylation
      Primary Target IC<sub>50</sub>2.5 µM
      Secondary targetphosphorylation of poly-GAT by the EGF receptor (IC₅₀ = 400 nM)
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      658402 0