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538916 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2

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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      A cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
      Catalogue Number538916
      Brand Family Calbiochem®
      Synonyms9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2
      References
      ReferencesGoessling, W., et al. 2009. Cell 136, 1136.
      Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
      Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.
      Product Information
      CAS number39746-25-3
      FormLiquid
      FormulationSupplied as a solution in methylacetate (1 mg/100 µL)
      Hill FormulaC₂₂H₃₆O₅
      Chemical formulaC₂₂H₃₆O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 11-36-66-67

      Highly flammable.
      Irritating to eyes.
      Repeated exposure may cause skin dryness or cracking.
      Vapors may cause drowsiness and dizziness.
      S PhraseS: 16-2-26-29-33

      Keep away from sources of ignition - No Smoking.
      Keep out of the reach of children.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Do not empty into drains.
      Take precautionary measures against static discharges.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      538916 0

      Documentation

      16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      538916

      References

      Reference overview
      Goessling, W., et al. 2009. Cell 136, 1136.
      Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
      Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-May-2010 RFH
      Synonyms9-Oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid, dmPGE2
      DescriptionA cell-permeable and orally available synthetic PGE2 (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE2 as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.
      FormLiquid
      FormulationSupplied as a solution in methylacetate (1 mg/100 µL)
      Intert gas (Yes/No) Packaged under inert gas
      CAS number39746-25-3
      Chemical formulaC₂₂H₃₆O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml), EtOH (100 mg/ml), PBS, pH 7.2 (5 mg/ml). Gently blow away methylacetate under a stream of N2, and solubilize in either DMSO or EtOH purged with an inert gas.
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.
      Toxicity Flammable
      ReferencesGoessling, W., et al. 2009. Cell 136, 1136.
      Fitzgerald, J., et al. 2000. Endocrinology 141, 291.
      Coleman, R.A., et al. 1994. Pharmacol. Rev. 46, 205.