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Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
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-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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505875
Sigma-Aldrich(+)-Bicuculline - CAS 485-49-4 - Calbiochem
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Description
Overview
A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
Catalogue Number
505875
Brand Family
Calbiochem®
Synonyms
GABAA Receptor Antagonist, Bicuculline
References
References
Ueno, S., et al. 1997. J. Neurosci.17, 625. Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89. Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187. Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.
Toxic by inhalation. Toxic in contact with skin. Very toxic if swallowed. May cause heritable genetic damage.
S Phrase
S: 22-28.1-36/37/39
Do not breathe dust. After contact with skin, wash immediately with plenty of water. Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
(+)-Bicuculline - CAS 485-49-4 - Calbiochem Certificates of Analysis
Title
Lot Number
505875
References
Reference overview
Ueno, S., et al. 1997. J. Neurosci.17, 625. Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89. Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187. Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
20-September-2013 JSW
Synonyms
GABAA Receptor Antagonist, Bicuculline
Description
A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
Form
Pale yellow solid
CAS number
485-49-4
Chemical formula
C₂₀H₁₇NO₆
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Ueno, S., et al. 1997. J. Neurosci.17, 625. Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89. Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187. Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.
