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324518 eIF4E/eIF4G Interaction Inhibitor II, 4E1RCat - Calbiochem

The eIF4E/eIF4G Interaction Inhibitor II, 4E1RCat controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati

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eIF4E/eIF4G Interaction Inhibitor II, 4E1RCat - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((3E)-3-((5-(4-Nitrophenyl)furan-2-yl)methylidene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid, eIF4F Inhibitor II

324518
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Áttekintés

Kulcsspecifikációk táblázata

Empirical Formula
C₂₈H₁₈N₂O₆

Products

KatalógusszámCsomagolás Menny./csomag
324518-10MG Üvegpalack 10 mg
Hozzáadás a Kedvencekhez
Description
OverviewA cell-permeable oxopyrrolyl benzoate compound that blocks the assembly of eukaryotic translation initiation factor (eIF) 4F complex (eIF4F) as well as disrupts preformed eIF4F by competing against eIF4G for eIF4E binding. Specifically blocks cap-dependent, but not cap-independent, protein translations in cell-free translation assays and inhibits protein, but not DNA or RNA, synthesis in MDA-MB-231 and HeLa cultures (50 µM) in a reversible manner. Although not effective when administered alone (15 mg/kg, i.p. daily for 5 days), 4E1RCat is shown to significantly prolong Pten+/-Eµ-myc and Tsc+/-Eµ-myc, but not Eµ-myc, tumor remission time when combined with Doxorubicin (Cat. No. 324380) treatment (10 mg/kg, i.p. once on day 2) in mice in vivo. Unlike 4EGI-1 (Cat. No. 324517), 4E1RCat also blocks eIF4E and 4E-BP1 interaction.
Catalogue Number324518
Brand Family Calbiochem®
Synonyms4-((3E)-3-((5-(4-Nitrophenyl)furan-2-yl)methylidene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid, eIF4F Inhibitor II
References
ReferencesCencic, R., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 1046.
Product Information
FormDark brown solid
Hill FormulaC₂₈H₁₈N₂O₆
Chemical formulaC₂₈H₁₈N₂O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥97% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsVery fluffy material, not recommended for subdividing solid material by hand-weighing. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
324518-10MG 04055977197334