Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

681669 Wnt Antagonist I, IWR-1-endo - Calbiochem

681669
Purchase on Sigma-Aldrich

Áttekintés

Kulcsspecifikációk táblázata

Empirical Formula
C₂₅H₁₉N₃O₃

Products

KatalógusszámCsomagolás Menny./csomag
681669-10MG Muanyagampulla 10 mg
Description
OverviewA cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. Also available as a 25 mM solution in DMSO (Cat. No. 504462).
Catalogue Number681669
Brand Family Calbiochem®
SynonymsTNKS1/2 Inhibitor II, Inhibitor of Wnt Response-1, Wnt Pathway Inhibitor I, Tankyrase1/2 Inhibitor II
References
ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Huang, S.M., et al. 2009. Nature 461, 614.
Product Information
FormOff-white solid
Hill FormulaC₂₅H₁₉N₃O₃
Chemical formulaC₂₅H₁₉N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
681669-10MG 04055977260274