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508146 WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem

WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635

Primary Target: 5-HT1A
508146
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
634908-75-1C₂₅H₃₄N₄O₂·C₄H₄O₄

Products

KatalógusszámCsomagolás Menny./csomag
5.08146.0001 Üvegpalack 10 mg
Description
OverviewA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
Catalogue Number508146
Brand Family Calbiochem®
Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
References
ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
Product Information
CAS number634908-75-1
FormOff-white solid
Hill FormulaC₂₅H₃₄N₄O₂·C₄H₄O₄
Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT1A
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.08146.0001 04055977242843

Documentation

WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Hunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
DescriptionA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
FormOff-white solid
CAS number634908-75-1
Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (50 mM). Warming is required for complete solubilization.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.