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504373 Vicriviroc Malate - CAS 541503-81-5 - Calbiochem

Vicriviroc Malate - CAS 541503-81-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690

Primary Target: CCR5
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
541503-81-5C₂₈H₃₈F₃N₅O₂·C₄H₆O₅
Description
Overview

This product has been discontinued.



A potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
Catalogue Number504373
Brand Family Calbiochem®
Synonyms(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
References
ReferencesBerro, R., et al. 2012. Virology 427, 158.
Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.
Product Information
CAS number541503-81-5
FormBeige powder
Hill FormulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
Chemical formulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCCR5
Primary Target IC<sub>50</sub>0.91 nM
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
504373 0

Documentation

Vicriviroc Malate - CAS 541503-81-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Berro, R., et al. 2012. Virology 427, 158.
Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-August-2013 JSW
Synonyms(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
DescriptionA potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
FormBeige powder
CAS number541503-81-5
Chemical formulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBerro, R., et al. 2012. Virology 427, 158.
Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.