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676380 Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem

Valproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.

Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Propylpentanoic Acid, Na

Primary Target: HDAC1
676380
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
1069-66-5C₈H₁₅O₂Na

Products

KatalógusszámCsomagolás Menny./csomag
676380-5GM Muanyagampulla 5 gm
Description
OverviewA cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
Catalogue Number676380
Brand Family Calbiochem®
Synonyms2-Propylpentanoic Acid, Na
References
ReferencesGottlicher, M., et al. 2001. EMBO J. 20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
Chen, G., et al. 1999. J. Neurochem. 72, 1327.
Product Information
CAS number1069-66-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₅O₂Na
Chemical formulaC₈H₁₅O₂Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationValproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.
Biological Information
Primary TargetHDAC1
Primary Target IC<sub>50</sub>400 µM
Purity≥98% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYV7876000
Safety Information
R PhraseR: 20/21/22-36/37/38-61

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause harm to the unborn child.
S PhraseS: 3/7/9-22-36/37/39-45

Keep container tightly closed, in a cool well ventilated place.
Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
676380-5GM 04055977183566

Documentation

Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem Certificates of Analysis

TitleLot Number
676380

References

Hivatkozások áttekintése
Gottlicher, M., et al. 2001. EMBO J. 20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
Chen, G., et al. 1999. J. Neurochem. 72, 1327.

Technical Info

Title
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Data Sheet

Title
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-April-2020 JSW
Synonyms2-Propylpentanoic Acid, Na
DescriptionA cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1069-66-5
RTECSYV7876000
Chemical formulaC₈H₁₅O₂Na
Structure formulaStructure formula
Purity≥98% by GC
SolubilityH₂O (50 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 9913
ReferencesGottlicher, M., et al. 2001. EMBO J. 20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674.
Chen, G., et al. 1999. J. Neurochem. 72, 1327.