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662107 UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem

662107
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
343351-67-8C₁₁H₉NO₅S

Products

KatalógusszámCsomagolás Menny./csomag
662107-25MG Üvegpalack 25 mg
Description
OverviewA cell-permeable nitrofuran compound that selectively inhibits the E2 Ubiquitin-conjugating enzyme Ubc13- (Cat. No. 438075), but not UbcH5c-, catalyzed K63-linked polyUb chain formation by preventing Ubc13-Ub thioester bond formation. Effectively inhibits Ubc13-Uev1A (UBE2V1) E2 complex-mediated NF-κB activation, Ubc13-Mms2 (UBEV2) E2 complex-mediated DNA DSB (double-strand break) repair activation, as well as Ubc13-dependent p53 nuclear export in cultures (1 to 2 µM). The combined NF-κB inhibition and p53 activation via Ubc13 inhibition is shown to be particularly effective against the proliferation of ABC (Activated B-cell-like) and GCB (Germinal center B-cell-like) DLBCL (Diffuse Large B-Cell Lymphoma) cell lines and primary DLBCL cultures via apoptosis induction (1 to 2 µM).
Catalogue Number662107
Brand Family Calbiochem®
SynonymsNSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor, 2-Nitro-5-tosylfuran, Ubc13 Inhibitor
References
ReferencesPulvino, M., et al. 2012. Blood 1668.
Product Information
CAS number343351-67-8
FormOff-white powder
Hill FormulaC₁₁H₉NO₅S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetUbc13
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
662107-25MG 04055977261202