Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

616390 Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem

Toxin II, Anemonia sulcata, CAS 60748-45-0, is a toxic polypeptide that specifically activates Na+ channels in excitable membranes. Mixture of isoleucine and valine isomers.

Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATX II

Primary Target: Na+ channel in excitable membranes
616390
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #
60748-45-0
Description
Overview

This product has been discontinued.



Mixture of isoleucine and valine isomers. Highly toxic polypeptide. Acts specifically on Na+ channel in excitable membranes, affecting neuromuscular transmission and mammalian heart muscle function. Augments Na+-dependent increase in twitch response and the duration of action potential. Has a positive inotropic effect on the heart.
Catalogue Number616390
Brand Family Calbiochem®
SynonymsATX II
References
ReferencesMantegazza, M., et al. 1998. J. Physiol. (London)507 (Pt. 1), 105.
Nishio, M., et al. 1991. Br. J. Pharmacol. 104, 504.
Wilheim, D., et al. 1991. Br. J. Pharmacol. 104, 483.
Berthold, H., et al. 1990. J. Pharmacol. Methods 24, 121.
Schreibmayer, W., et al. 1987. Biochim. Biophys. Acta 901, 273.
Alsen, C. 1983. Fed. Proc. 42, 101.
Product Information
CAS number60748-45-0
ATP CompetitiveN
FormLyophilized solid
ReversibleN
Quality LevelMQ100
Applications
ApplicationToxin II, Anemonia sulcata, CAS 60748-45-0, is a toxic polypeptide that specifically activates Na+ channels in excitable membranes. Mixture of isoleucine and valine isomers.
Biological Information
Biological activity≤5 µg/kg (tested with shore crabs)
Primary TargetNa+ channel in excitable membranes
PurityApproximately 40% ATX II-Ile, 40% ATX II-Val, and 20% other isotoxins by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCK4438200
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
616390 0

Documentation

Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Toxin II, Anemonia sulcata - CAS 60748-45-0 - Calbiochem Certificates of Analysis

TitleLot Number
616390

References

Hivatkozások áttekintése
Mantegazza, M., et al. 1998. J. Physiol. (London)507 (Pt. 1), 105.
Nishio, M., et al. 1991. Br. J. Pharmacol. 104, 504.
Wilheim, D., et al. 1991. Br. J. Pharmacol. 104, 483.
Berthold, H., et al. 1990. J. Pharmacol. Methods 24, 121.
Schreibmayer, W., et al. 1987. Biochim. Biophys. Acta 901, 273.
Alsen, C. 1983. Fed. Proc. 42, 101.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2009 JSW
SynonymsATX II
DescriptionMixture of isoleucine and valine isomers. Highly toxic polypeptide. Acts specifically on the Na+ channel in excitable membranes, affecting neuromuscular transmission and mammalian heart muscle function. Augments the Na+-dependent increase in twitch response and the duration of action potential. Has a positive inotropic effect on the heart.
FormLyophilized solid
CAS number60748-45-0
RTECSCK4438200
PurityApproximately 40% ATX II-Ile, 40% ATX II-Val, and 20% other isotoxins by HPLC
Biological activity≤5 µg/kg (tested with shore crabs)
SolubilityH₂O (2 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C).
Toxicity Harmful
ReferencesMantegazza, M., et al. 1998. J. Physiol. (London)507 (Pt. 1), 105.
Nishio, M., et al. 1991. Br. J. Pharmacol. 104, 504.
Wilheim, D., et al. 1991. Br. J. Pharmacol. 104, 483.
Berthold, H., et al. 1990. J. Pharmacol. Methods 24, 121.
Schreibmayer, W., et al. 1987. Biochim. Biophys. Acta 901, 273.
Alsen, C. 1983. Fed. Proc. 42, 101.