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614852 Topoisomerase IIα Inhibitor, TSC24 - Calbiochem

The Topoisomerase IIα Inhibitor, TSC24 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Topoisomerase IIα Inhibitor, TSC24 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-N,N-dimethyl-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide

614852
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₁₃H₁₄N₄S

Products

KatalógusszámCsomagolás Menny./csomag
614852-10MG Üvegpalack 10 mg
Description
OverviewA cell-permeable, TSC (thiosemicarbazone) derivative that acts as a selective and ATP competitive Topoisomerase IIα inhibitor and Fe chelator. Independent of its Fe chelating ability, this compound is shown to block Topo II&alpha-catalyzed ATP hydrolysis by competing with ATP for binding to the ATPase domain of Topo IIα (Kd = 18 µM). It also displays M phase cell-cycle arrest at 1 µM in nocodazole-treated HT-29 cells. This compound demonstrates anti-proliferative activity, without distinct or obvious selectivity, towards HeLa, HL-60, SGC7901, and HT-29 cultures (IC50 = 90 nM, 50 nM, 30 nM, and 20 nM, respectively), and a broader panel of tumor cell lines with IC50 values in the nanomolar range.
Catalogue Number614852
Brand Family Calbiochem®
Synonyms(E)-N,N-dimethyl-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide
References
ReferencesHuang, H., et al. 2010. J. Med. Chem. 53, 3048.
Product Information
FormYellow powder
Hill FormulaC₁₃H₁₄N₄S
Chemical formulaC₁₃H₁₄N₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
614852-10MG 04055977186352

Documentation

Topoisomerase IIα Inhibitor, TSC24 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Topoisomerase IIα Inhibitor, TSC24 - Calbiochem Certificates of Analysis

TitleLot Number
614852

References

Hivatkozások áttekintése
Huang, H., et al. 2010. J. Med. Chem. 53, 3048.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
Synonyms(E)-N,N-dimethyl-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide
DescriptionA cell-permeable, TSC (thiosemicarbazone) derivative that acts as a selective and ATP competitive Topoisomerase IIα inhibitor and Fe chelator. Independent of its Fe chelating ability, this compound is shown to block Topo II&alpha-catalyzed ATP hydrolysis by competing with ATP for binding to the ATPase domain of Topo IIα (Kd = 18 µM). It also displays M phase cell-cycle arrest at 1 µM in nocodazole-treated HT-29 cells. This compound demonstrates anti-proliferative activity, without distinct or obvious selectivity, towards HeLa, HL-60, SGC7901, and HT-29 cultures (IC50 = 90 nM, 50 nM, 30 nM, and 20 nM, respectively), and a broader panel of tumor cell lines with IC50 values in the nanomolar range.
FormYellow powder
Chemical formulaC₁₃H₁₄N₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (15 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHuang, H., et al. 2010. J. Med. Chem. 53, 3048.