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614320 Toll-Like Receptor 7 Ligand II

Toll-Like Receptor 7 Ligand II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine, 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

614320
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
226907-52-4C₁₅H₁₇N₅O₃
Description
Overview

This product has been discontinued.





A cell-permeable hydroxyadenine compound that acts as a potent and highly specific TLR7 (toll-like receptor 7) agonist without any detectable activity towards TLR2/3/5/8/9. Shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro and exhibit excellent oral bioavailability in mice in vivo with ~100-fold higher plasma IFN-inducing activity than Imiquimoid (Cat. No. 401020).
Catalogue Number614320
Brand Family Calbiochem®
Synonyms9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine, 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
References
ReferencesJin, G., et al. 2006. Bioorg. Med. Chem. 16, 4559.
Lee, J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1828.
Kurimoto, A., et al. 2004. Bioorg. Med. Chem. 12, 1091.
Product Information
CAS number226907-52-4
FormWhite solid
Hill FormulaC₁₅H₁₇N₅O₃
Chemical formulaC₁₅H₁₇N₅O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
614320 0

Documentation

Toll-Like Receptor 7 Ligand II Certificates of Analysis

TitleLot Number
614320

References

Hivatkozások áttekintése
Jin, G., et al. 2006. Bioorg. Med. Chem. 16, 4559.
Lee, J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1828.
Kurimoto, A., et al. 2004. Bioorg. Med. Chem. 12, 1091.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine, 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
DescriptionA cell-permeable hydroxyadenine compound that acts as a potent and highly specific TLR7 (toll-like receptor 7) agonist without any detectable activity towards TLR2/3/5/8/9. Shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro and exhibit excellent oral bioavailability in mice in vivo with ~100-fold higher plasma IFN-inducing activity than Imiquimoid (Cat. No. 401020).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number226907-52-4
Chemical formulaC₁₅H₁₇N₅O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesJin, G., et al. 2006. Bioorg. Med. Chem. 16, 4559.
Lee, J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1828.
Kurimoto, A., et al. 2004. Bioorg. Med. Chem. 12, 1091.