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574775 Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem

574775
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
72741-87-8C₈H₁₅NO₃

Products

KatalógusszámCsomagolás Menny./csomag
574775-500UG Muanyagampulla 500 μg
Description
OverviewReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
Catalogue Number574775
Brand Family Calbiochem®
Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
References
ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
Elbein, A.D. 1983. Methods Enzymol. 98, 135.
Product Information
CAS number72741-87-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₅NO₃
Chemical formulaC₈H₁₅NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetLysosomal α-mannosidase
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
574775-500UG 04055977189711

Documentation

Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem Certificates of Analysis

TitleLot Number
574775

References

Hivatkozások áttekintése
Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
Elbein, A.D. 1983. Methods Enzymol. 98, 135.

Citations

Titulus
  • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-September-2008 RFH
    Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
    DescriptionReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
    FormWhite solid
    CAS number72741-87-8
    Chemical formulaC₈H₁₅NO₃
    Structure formulaStructure formula
    Purity≥98% by TLC
    SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or Chloroform
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Harmful
    ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
    Elbein, A.D. 1983. Methods Enzymol. 98, 135.
    Citation
  • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.