573121 Sigma-AldrichSMER28 - CAS 307538-42-7 - Calbiochem
A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.
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Synonyms: (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
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Áttekintés
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Kulcsspecifikációk táblázata
| CAS # | Empirical Formula |
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| 307538-42-7 | C₁₁H₁₀BrN₃ |
Products
| Katalógusszám | Csomagolás | Menny./csomag | |
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| 573121-10MG | Muanyagampulla | 10 mg |
| Description | |
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| Overview | A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR. |
| Catalogue Number | 573121 |
| Brand Family | Calbiochem® |
| Synonyms | (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II |
| References | |
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| References | Tian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331. |
| Product Information | |
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| CAS number | 307538-42-7 |
| Form | Pale yellow solid |
| Hill Formula | C₁₁H₁₀BrN₃ |
| Chemical formula | C₁₁H₁₀BrN₃ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Katalógusszám | GTIN |
| 573121-10MG | 04055977266054 |
Documentation
SMER28 - CAS 307538-42-7 - Calbiochem MSDS
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SMER28 - CAS 307538-42-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 573121 |
References
| Hivatkozások áttekintése |
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| Tian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331. |