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559406 SB 328437 - CAS 247580-43-4 - Calbiochem

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

SB 328437 - CAS 247580-43-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate

Primary Target: CC chemokine receptor-3 (CCR3)
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
247580-43-4C₂₁H₁₈N₂O₅
Description
OverviewA highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4 with IC50 values of 38, 35, and 20 nM, respectively. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis (IC50 values: 32, 25, and 55 nM, respectively).
Catalogue Number559406
Brand Family Calbiochem®
Synonyms(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
References
ReferencesWhite, J.R., et al. 2000. J. Biol. Chem. 275, 36626.
Product Information
CAS number247580-43-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₁H₁₈N₂O₅
Chemical formulaC₂₁H₁₈N₂O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCC chemokine receptor-3 (CCR3)
Primary Target IC<sub>50</sub>38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
559406 0

Documentation

SB 328437 - CAS 247580-43-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

SB 328437 - CAS 247580-43-4 - Calbiochem Certificates of Analysis

TitleLot Number
559406

References

Hivatkozások áttekintése
White, J.R., et al. 2000. J. Biol. Chem. 275, 36626.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
DescriptionA highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of 125I-eotaxin and 125I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC50 = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC50 = 38, 35, and 20 nM, respectively).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number247580-43-4
Chemical formulaC₂₁H₁₈N₂O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWhite, J.R., et al. 2000. J. Biol. Chem. 275, 36626.